Mane is a doubt for the trip to Turf Moor following a shoulder injury he picked up in training this week.
Liverpool will have been breathing some of a sigh of relief last night as it emerged that the shoulder injury sustained by Sadio Mane in training does not seem to be a serious one.
Mane already seems to have emerged as a key player to the Reds chances of enjoying a successful season following a stunning debut display in the 4-3 win over Arsenal at the weekend - with both his pace and end product causing the Gunners some nightmares.
The Liverpool Echo reports that he is unlikely to be available for the weekend's trip to Turf Moor to take on Burnley.
Liverpool manager Juergen Klopp
Though it may not be for too long, there will have to be a change to the Reds frontline that was so devastating in that win over Arsenal at the weekend for a very different task of taking on one of the league's newly promoted sides.
The trio of Mane, Philippe Coutinho and Roberto Firmino seemed to work well up front but with one pacey player out of the side for the weekend, you'd think another would come in.
But both of the main candidates afforded to Jurgen Klopp are likely to be central strikers. Divock Origi came on as a substitute against Arsenal while Daniel Sturridge is in line for a return to the side after missing the season opener with a minor hip injury.
Daniel Sturridge celebrates after scoring the second goal for Liverpool
If they are to play through the middle then that will likely mean a change in position for Roberto Firmino - whether he drops deeper with a slight change in system, or he takes up a wider role.
Klopp certainly doesn't want to lose the potency and pace that his side had at the Emirates Stadium so he will be looking for his front three to be fluid, regardless of who lines up in the side.
Some would suggest that the most natural replacement would be Lazar Markovic who is on the fringes of the side - but given he was omitted from the squad entirely for the trip to the Emirates, and seeming lack of confidence in his own ability in front of goal whenever he's played for the club, that would be an unlikely move.
It's hard to look beyond either Sturridge or Origi. Origi showed great form in pre-season and could be given the nod ahead of Sturridge who is returning from injury - though there could be room for both players to play. But Klopp's selection up front will say a lot about his intent going into this fixture.
Liverpool's Divock Origi celebrates scoring their third goal