New manager Antonio Conte takes charge of his first Premier League game having replaced Guus Hiddink this summer, and despite suggestions that he could go with a 3-5-2 or 4-2-4 system, he seems to gone with a 4-1-4-1 formation.
Summer signing N'Golo Kante starts in front of the back four, with Nemanja Matic and Oscar ahead of him in central midfield, whilst Eden Hazard and Willian will start out wide.
Diego Costa leads the line despite rumours over his future, whilst a familiar back four of Branislav Ivanovic, Gary Cahill, John Terry and Cesar Azpilicueta start once again.
Conte has named the likes of Victor Moses, Pedro and Cesc Fabregas on the bench, whilst new signing Michy Batshuayi as well as youngsters Ola Aina and Ruben Loftus-Cheek are also substitutes.
Meanwhile, West Ham United will be hoping to spring another away day shock having beaten the likes of Arsenal, Liverpool and Manchester City away from home last season.
These are exciting times for the Hammers having moved into the London Stadium, and manager Slaven Bilic has been backed in the transfer market as three summer signings start tonight.
Left back Arthur Masuaku starts in place of the injured Aaron Cresswell, Havard Nordtveit will protect the back four in a holding midfield role, whilst Andre Ayew starts on the right hand side of midfield.
There are starts for familiar faces such as Mark Noble, Cheikhou Kouyate and Andy Carroll, whilst Michail Antonio continues at right back.
Star man Dimitri Payet is on the bench having played at Euro 2016 for France, as is summer signing Gokhan Tore as well as the likes of Reece Oxford, Pedro Obiang, Angelo Ogbonna and Sam Byram.
- Thibaut Courtois
- César Azpilicueta
- Gary Cahill
- Branislav Ivanovic
- John Terry
- Eden Hazard
- N'Golo Kanté
- Nemanja Matic
- Diego Costa
Substitutes: Asmir Begovic, Ola Aina, Cesc Fàbregas, Ruben Loftus-Cheek, Victor Moses, Michy Batshuayi, Pedro.
- James Collins
- Arthur Masuaku
- Winston Reid
- Michail Antonio
- Cheikhou Kouyaté
- Mark Noble
- Håvard Nordtveit
- André Ayew
- Andy Carroll
- Enner Valencia
Substitutes: Darren Randolph, Sam Byram, Angelo Ogbonna, Reece Oxford, Pedro Obiang, Dimitri Payet, Gökhan Töre.
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