Wales' Ashley Williams
Ronald Koeman admitted that new signing Ashley Williams is not yet considered match-fit and will not feature on Saturday - in quotes posted on the club's Twitter account - meaning he will have to look elsewhere to fill the John Stones shaped void.
Everton's Romelu Lukaku
Romelu Lukaku and Seamus Coleman are also doubts with heel and ankle problems, respectively. Mo Besic, Tyias Browning and Matthew Pennington are the other absentees leaving Koeman with something of a selection headache.
The Everton boss also admitted that the squad as a whole are not at the level they need to be and Mauricio Pochettino will hope to capitalise come Saturday.
Belgium's Jan Vertonghen listens to questions during a news conference
Spurs are practically at full-strength, with Jan Vertonghen’s return a welcome boost in the heart of defence.
Moussa Dembele still has a four-game ban to serve while Heung-Min Son is currently representing South Korea at the Olympics, but there are no injury concerns ahead of the new campaign.
Goodison Park is a notoriously tricky venue but given the contrasting health of both team’s squads, Spurs will be confident of kicking off their Premier League season with a three point haul.