West Ham manager Slaven Bilic
The Hammers have already played two competitive matches this summer in the Europa League and beat Slovenian side NK Domzale 4-2 over two legs recently.
Chelsea are under new management in the form of Italian taskmaster Antonio Conte and are being tipped to mount a serious title challenge following last season's spectacular collapse.
The London rivals clash in the opening game of Conte's reign at Stamford Bridge on Monday night.
Sky Sports pundit Jamie Redknapp
'I can't wait for this one'
"I can't wait to watch this game, normally this match between these two sides is very spicy, a few tackles going in and I expect this one to be no different," Redknapp told Sky Sports.
"(Conte) gets his team up and at 'em and there's no doubt Chelsea will be extremely fit and they won't be anything like they were last year.
"They're playing against a West Ham side that had a brilliant season, plenty of good players and I think in Payet one of the most enjoyable players to watch in the Premier League.
Chelsea's manager Antonio Conte gestures
"Hard to predict this one, but I am going to edge towards Chelsea, I think home advantage, there'll be a feel good factor about having a new manager there and I think they might just edge it, 2-1 Chelsea."
Hammers boss Slaven Bilic will of course be hoping to emulate last season's brilliant start when they travelled to another London rival expected to challenge for the title in the shape of Arsenal.
His side dominated the game as West Ham looked fitter and hungrier than their North London hosts and came away with a deserved 2-0 win.
Hammers fans will be hoping for a repeat this season but one thing is for certain Conte will not tolerate a sluggish performance from his new charges.
Fully focused: Bilic
Revenge on the menu
Revenge is on the menu for the East Londoners as that draw, followed up by another 2-2 draw with Crystal Palace as a result of a refereeing blunder, ended up costing Bilic's side a place in the Champions League.