Tottenham should have at least one hugely capable replacement in Kevin Wimmer.
Tottenham's Jan Vertonghen
As the Belgian star continues his return from the ankle injury that interrupted his European Championships, seemingly ahead of schedule from the initial return forecast for him, Mauricio Pochettino should withstand the temptation to put him straight back into the Spurs side for the Premier League opener against Everton this weekend.
Tottenham's Kevin Wimmer reacts
Kevin Wimmer is the obvious individual to come in for Vertonghen, having fared so well in the former Ajax man's absence last season.
A small concern for fans is that Wimmer has failed to make an appearance in the club's preseason matches in Australia and Oslo.
But there has been no word coming from Pochettino that the Austrian has an injury to worry about, with it instead feasible that he wanted to give Cameron Carter-Vickers and Anton Walkes as many opportunities as possible before the season.
Republic of Ireland's Seamus Coleman in action with Belgium's Jan Vertonghen
Vertonghen returned to full training from a serious knee injury in the last couple of months of the Premier League season, and was quickly put back into the Spurs side alongside his compatriot Toby Alderweireld. If anything, Spurs looked less secure at times at the back once the Belgians were reunited, something that may have been a result of Vertonghen coming back in for such important matches.
Wimmer on the other hand had a right to be disappointed at being moved to, and then staying on the bench. The former Cologne defender signed a new contract this summer, and as a quality defensive option should be trusted to step in for Vertonghen in situations like this. This should then benefit the Belgian for the season, as he is gradually brought back into the starting lineup and building up his fitness and confidence in the absence of a full and proper preseason.
And if Wimmer was unavailable against Everton, it would still be better for Pochettino to resist the temptation to throw in Vertonghen for the defender's own good, with Carter-Vickers demonstrating against Inter recently that in a full strength side he can do a job.
Tottenham's Jan Vertonghen and Harry Kane celebrate