The West Yorkshire outfit will take on QPR away from home at Loftus Road in London on Sunday afternoon.
Monk, who was appointed the Leeds head coach in the summer following the departure of Steve Evans, rates Rangers highly.
The former Swansea City manager believes that Jimmy Floyd Hasselbaink’s side are strong contenders to get promoted to the Premier League at the end of the 2016-17 campaign.
“QPR are one of those teams that have been in the Premier League in recent seasons so they have still got a nucleus of squad that had that experience of being in the Premier League and of promotion,” Monk told The Yorkshire Evening Post.
“They will be strong candidates this year to be up there, in and around those promotion spots so it will be a very tough opener for us.”
Leeds have been quite busy in the summer transfer window so far, signing Marcus Antonsson, Robert Green, Kemar Roofe, Kyle Bartley and Pablo Hernandez, amongst others.
The Whites have not featured in the Premier League since 2004, but this season they could launch a serious challenge for the top six.
If Leeds are able to make a strong start to the season and pick up points, then anything is possible.
The Whites will head into the game against QPR at Loftus Road in London with confidence.