Derby and Brighton will face each other in the Championship on Saturday afternoon.
“Brighton are going to be incredibly difficult to beat again this season,” Holloway told Sky Sports while predicting a 1-1 draw. “Chris Hughton is a master of his trade.
“This might be a tricky opener for them though as Nigel Pearson will be looking to make an early splash with his new Derby players.
“How quickly will they adapt to his methods? It's impossible to tell, but they have enough quality to avoid defeat here.”
Brighton had a very successful season in 2015-16 and were perhaps unlucky not to get promoted to the Premier League.
The Seagulls will be expected to fight for a top-two finish in the Championship this campaign.
Playing at home will give Derby an advantage, with Nigel Pearson’s also one of the favourites for promotion.
The Rams will fancy their chances against Brighton, and one should not be surprised if the home team eke out a narrow win.
Holloway has also given his thoughts on the Championship clash between Rotherham United and Wolverhampton Wanderers.
Rotherham and Wolves will take on each other at the AESSEAL New York Stadium on Saturday afternoon.
“It was a tough call to get rid of Kenny Jackett - he did a brilliant job to get the club promoted then stabilise them in the Championship,” Holloway told Sky Sports while predicting a 1-1 draw.
“I’m not sure how the new-look big-spending Wolves will get on, especially if they're being guided by agents in terms of their recruitment. That doesn't always work.
“I just hope it doesn't go the same way as Blackburn did under Jerome Anderson. You have to be careful in football - it's very different to any other business. It's very people orientated.”
Rotherham will be expected to fight for survival in the Championship this season, while Wolves should be pushing at least for a top-10 finish in the league table during the 2016-17 campaign.