The Brewers begin their first ever campaign in the second tier against Nottingham Forest this weekend.
Clough admits his side will find it tough next season
The coming campaign is Burton's first in the second tier of English football, starting with a trip to Nottingham Forest this weekend, before contests with Bristol City, Sheffield Wednesday, Blackburn Rovers and Derby County, giving the Brewers a tough start.
And Clough admits that his side will find it hard to cope with the demands of the Championship, telling BBC Radio Derby: "The teams we're playing in this spell puts the size of the challenge we're facing into perspective.
"You look through the fixtures and wonder where we're getting a point from sometimes, never mind a win."
Many pundits have tipped the Brewers to go straight back down to League One this season, but Clough says the unpredictability of the division means they cannot be written off.
"It's important that we get off to good start [against Forest] on Saturday," he added. "It's impossible to predict, that's been the nature of the Championship over the last few seasons."
Clough's side have been boosted by the news they are set to re-sign 18-year-old midfielder Hamza Choudhury on a season-long loan from Premier League champions Leicester City.
Choudhury played a key role in helping Albion win promotion to the Championship last season during a three-month loan at the Pirelli Stadium, and Clough is delighted to welcome the teenager back to the club.
"We've agreed a deal in principal but it's not signed. The bones are there. We hope it will be done by Saturday," he added.