The Arsenal midfielder has been ruled out with another injury.
The midfielder was hoping to be over his injury troubles after getting himself fit this summer and travelling to Euro 2016 with England.
However, he has picked up a knee injury during their pre-season trip to America, sitting out the weekend win over Chivas.
He is also set to miss their trip to Scandinavia and that has led to fears he will now be set for another long spell on the sidelines.
It now remains to be seen whether that is the case, with the midfielder hoping for an injury-free season after missing the majority of the last campaign with an ankle injury.
Even if he does manage to prove his fitness he is facing a fight to get into the Gunners' midfield.
They have a number of options in central midfield and have added Granit Xhaka this summer, meaning Wilshere may find himself down the pecking order.