The Reds goalkeeper has suffered a broken hand and will miss two months of the season.
Liverpool's Loris Karius
Liverpool fans have taken to Twitter to react to the news that Loris Karius is set for an extended spell on the sidelines after breaking his hand.
The German goalkeeper is one of seven new faces at Anfield this summer in what has been a busy transfer window for Jurgen Klopp.
He arrived earlier in the summer, with the German boss looking to bring in stern competition for number one Simon Mignolet.
Liverpool's Simon Mignolet
The Belgian came in for criticism yet again last season after several unimpressive displays once again for the Reds.
Indeed, Reds fans had been hoping that Karius was being brought in to replace Mignolet as first choice next season.
Liverpool's Loris Karius (2nd L) in action
That is not going to be the case at first though, as he has broken his hand following a collision with Dejan Lovren in the recent clash with Chelsea, according to the Daily Mail.
The German U-21 international is now set to be out for up to two months with the injury, which will see him miss games against Arsenal, Leicester, Chelsea and Tottenham Hotspur.
Liverpool's Loris Karius warms up before the match
And reacting to the news on Twitter, it is fair to say Liverpool fans were mostly devastated by the news.
Can we just have a one handed Karius I'd have that over Mignolet any day— Justin Bieber News (@biebersgiIinsky) July 29, 2016
Loris Karius injured. This is not what I wanted to hear today. Gutted. Mignolet better play like his life depends on it!!!! #LFC— Klopp Of The League (@mjsportfan) July 29, 2016
It's like a curse every time Mignolet is about to be replaced the other keeper gets injured. Happened with Brad Jones and now Karius ffs— Matt (@LallanaTurns) July 29, 2016
Genuinely think I'd rather Karius in a cast over Mignolet.— 2kNicksteen (@Vondopoulos) July 29, 2016
Karius, Matip, Sakho, Gomez, Grujic. Without LB and back-up RB i do think Klopp needs to sort this issue real quick.— Farid SMJ (@faridsmj) July 29, 2016
Karius injury is a blow but not a disaster mignolet will be ok with new defensive cover, staying positive & no don't wanna argue the point— Mike Hassey (@MikeHassey_LFC) July 29, 2016
Only thing for it now sign Neuer lads @LFC he's the next best German keeper after Karius anyway— Saif (@saifmahmood1) July 29, 2016
Karius injured an out the team till mid October is an absolute nightmare— Asbvaluebets (@asbvaluebets) July 29, 2016
Karius out for two months, this injury curse is ongoing from last season! #LFC— Aaron Azza Suarez ॐ (@shezminex) July 29, 2016
Surely a one handed Karius is still better than a 2 handed Mignolet! #LFC— Rob Rilovic (@Rilovic) July 29, 2016
Hope the injury doesn't affect Karius in the long-term.— Rise Of The Klopp (@RiseOfTheKlopp) July 29, 2016