Given will leave behind him a long and well-remembered career wearing green, having made his debut for his country's senior side two decades ago in 1996.
The 40-year-old brings down the curtain on his time with the national side having won 134 caps for the boys in green, a total which is behind only captain and stalwart striker Robbie Keane.
Given initially retired from international football four years ago after Euro 2012, but that lasted just five months until he made himself available for selection once again at the start of 2013.
In 2014, two years after his previous appearance, he made his comeback in a friendly, and by last year he had regained his place in Martin O'Neill's first-choice squad despite playing very little club football for Stoke or previous club Aston Villa.
Though he did not play a single minute, he travelled as the most senior figure in O'Neill's squad to Euro 2016 as Ireland reached the last 16, but he has now retired from Ireland duty for a second time.
After his announcement on Thursday, Irish fans responded with an overwhelming show of support and gratitude for their former hero, with many labelling him the greatest goalkeeper ever to pull on the country's shirt.
Sad to see Shay Given retire from International football. Ireland's greatest ever goalkeeper ⚽ #Legend— Michaela Langan (@Michaela_Langan) July 28, 2016
Thanks for everything @No1shaygiven ! One of the worlds best in his prime! ☘— MaciekB❄ (@MaciekB_98) July 28, 2016
@No1shaygiven Congrats on a great international career and cheers for the memories. Ireland's greatest ever goalkeeper without question.— Daniel Collins (@DanielCollins85) July 28, 2016
Shay Given really is an international legend, hero— Liam (@Liam67M) July 28, 2016
What a great professional and top class keeper @No1shaygiven has been for Ireland...— Paul Phelan (@Pheo7) July 28, 2016
Farewell (again) Shay Given. Best Irish keeper of my football watching career and I'd imagine the same for most Irish fans on here.— Gerard Farrell (@gerrytastic) July 28, 2016