The 30-year-old Croatian made only 24 Serie A starts for the Old Lady last term, and with Higuain's reported arrival his playing time will be even further limited, as the Turin club will surely start someone they have just splashed out £79 million on.
With Juventus likely to be willing to offload someone in the striker department for both financial and squad size reasons, Leicester City should consider an ambitious move for the former Bayern Munich and Atletico Madrid marksman.
Mandzukic during his time at Bayern
His pedigree within the game is unquestionable, and he is still one of the finest strikers in European football. If he were to make a move to the Foxes, he would instantly lift them to a different level. He could strike up a frightening partnership with Jamie Vardy and both player's games would compliment each other's perfectly.
On paper, Leicester attempting to sign someone of Mandzukic's calibre seems a little far stretched, but the Midlands club can now operate in a totally different market after their heroics last season saw them finish as Premier League champions.
They can offer potential signings Champions League football and have increased spending power due to the new Premier League TV deal and the £32 million sale of N'Golo Kante.
N'Golo Kante's sale has increased Leicester's spending power even further
If the Foxes were to offer the Croatian guaranteed first-team football, it is not out of the question that he would consider a move to the Premier League champions. His contract with the Italian giants does not expire until the summer of 2019, and he moved to Turin for a fee of around £15 million last summer, so Juventus would surely want to recoup at least what they paid for him.
Claudio Ranieri should, nevertheless, consider a move for Mandzukic, and increase his options in forward areas for what will be one of the toughest Premier League campaigns he has had to manage.
Leicester manager Claudio Ranieri must improve his squad in order to compete again next term