Mark Warburton's Glasgow Rangers side travel to Fir Park for their first game of the season.
Louis Moult scoring for Motherwell
The two Scottish Premiership sides kick off their seasons against one another following the introduction of a new format in the competition that involves the first round being played over a group stage.
Rangers manager Mark Warburton
With the two sides likely to be heavy favourites to finish in the top two of their respective group, it seems probable that the winner on the opening day will be the team that tops the standings and is not relying on being one of the four best runners-up.
The game could also allow one of the sides to strike a psychological blow ahead of the league campaign as Well will be hoping to hold off any challenge that the Light Blues make to try and move above them in the table.
And Moult - who the Evening Times reports, is a doubt for the game due to injury - has outlined how his side should play to strike that psychological blow.
"We played the likes of Celtic last season, and the one that sticks out in my mind was when they came to our place and we sat off them in the first half, but in the second half we got at them and caused them a few problems and we nearly beat them, so that's what we've got to do to Rangers," he told the Evening Times.
"People will make us the underdogs, that's for sure, and I definitely prefer being the underdog. I love proving people wrong."