It is feared that Vertonghen is set for an extended spell on the sidelines after suffering an ankle injury on international duty.
Vertonghen injured his ankle in Belgium training on Wednesday night less than 48 hours before his country's Euro 2016 quarter-final against Wales and there were early fears that he could miss up to four months, although it has since been confirmed that his absence will be more like six to eight weeks.
The defender, who made 33 appearances in all competitions for Spurs last term and has played the full 90 minutes in each of Belgium's four games at Euro 2016 so far, confirmed on Twitter on Thursday that his tournament in France was over.
Gutted to say that my Euros is over. Good luck to my teammates for the rest of the competition— Jan Vertonghen (@JanVertonghen) June 30, 2016
Though it is undoubtedly a huge blow for Belgium's hopes of European glory, given that fellow defender Thomas Vermaelen has also picked up a problem, things may not be as bad as they seem for Spurs.
That's because between late January and mid-April, when the centre-back was also on the sidelines, deputy defender Kevin Wimmer stepped up to the plate impressively.
The 23-year-old, who was signed by Mauricio Pochettino from German side Koln last summer, had looked promising in domestic cup and Europa League appearances before he was handed his Premier League debut as a substitute for the injured Vertonghen against Crystal Palace on 23 January.
Following that first appearance the Austrian would go on to start the club's next 15 matches in all competitions and form his own impressive partnership with first-choice Toby Alderweireld in the heart of defence.
Though Vertonghen's injury leaves Spurs low on options at the back, the club's supporters on Twitter have gone as far as to suggest that Wimmer's presence means that the older player's absence will not be felt too heavily next term.
Shame about Vertonghen but Wimmer has already proved he's a more than able back up— Sebastian (@Sebastian__4) June 30, 2016
Not too worried about Wimmer playing instead of Vertonghen for 4 months. Problem comes when we need to rotate. CB needed?— Zigzag (@Zigzag73) June 30, 2016
Tbh I was kinda bummed when Vertonghen was cleared to return from injury last year. Wimmer was class. #OnwardAndUpward— Sonny Daze (@natecancook) June 30, 2016
Not even slightly worried about Vertonghen being out. Wimmer is superior anyway, it'll give him time to cement his place in the team. #thfc— Harry (@harryjgraham) June 30, 2016
Wimmer was brilliant when he stepped in for Vertonghen . Hopefully he can now cement his place for good .— Philip Morris (@PhilipJonMorris) June 30, 2016
People worrying about Vertonghen being out? If Wimmer plays how he did last year, Jan will be worrying how he gets back in.— Guy Brinkley (@GSPCECOYS) June 30, 2016
Vertonghen out for 4 months, sad, but I prefer Alderweireld-Wimmer, he's becoming injury prone lately maybe we need a CB comfortable L & RCB— B o r n F r e e J o (@Born_Free_Jo) June 30, 2016
Vertonghen being injured is not as bad as it seems with Wimmer stepping in like the last time and Davies playing at CB for Wales we're fine— Jordan (@JHiggsEburne) June 30, 2016
Another injury for Vertonghen Gutted for him and I wish him a speedy recovery but I know Wimmer will step in and be quality— Makeshift (@Mahesh_Parkar) June 30, 2016
If this news about vertonghen is true, I'm not half as worried as I should be, wimmer has shown that he's perfectly capableof 1st teamaction— -/- (@RobertoCarlrose) June 30, 2016
Vertonghen injury would be horrible. But Wimmer stepped up comfortably. Not too concerned, but not ideal.— Bamidele. (@LiamJM10TV) June 30, 2016
IF Vertonghen is out longterm at least we have Wimmer who played well filling in for Jan last season. #COYS— Chad Smith (@Chadwicks22) June 30, 2016
Last time we were all worried about Vertonghen being injured, Wimmer stepped in and we barely noticed a difference. We'll be fine.— Spurs In The Blood (@SpursInTheBlood) June 30, 2016