Thursday's referendum result means the UK will need to renegotiate its trade relationship with the European Union - including whether it remains part of the single market.
John Cryan, chief executive of Deutsche Bank, said he thought London would lose some of its status as a financial hub.
"The financial centre won't die, but it will get weaker," he told German business newspaper Handelsblatt.
Mr Cryan did not comment on the possible impact of the leave decision on Deutsche Bank, which employs at least 11,000 staff in the UK.
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