The Italian enjoyed a good start to his Manchester United career but a lack of form and fitness derailed that promising beginning to life at the Theatre of Dreams.
Darmian, a £12 million signing from Torino, was brought to the club by Louis van Gaal but, with Mourinho now in charge, his future looks less certain.
Given that he is not his player, the Portuguese manager is unconvinced by the 26-year-old and Tuttosport claim that one of Mourinho's first acts as United boss will be to sell him.
The right-back position is one that has plagued the Red Devils since Gary Neville retired. Plenty have tried and failed to fill that void, with the likes of Rafael, Antonio Valencia and, at times, Ashley Young being deployed there.
Darmian managed 24 Premier League starts for Manchester United this past season, scoring once but failed to provide a single assist in any competition, which may raise questions over his usefulness in the final third.
His stock is obviously high in Italy following his move from a Serie A club last summer, and the report goes on to claim that Juventus are among those interested.
Mourinho leaves his house in London