The goalkeeper will be hoping to help his side to their second consecutive major tournament triumph.
HITC Sport writers have compiled a list of the top 50 players at Euro 2016, assessing players from across the 24 countries taking part at this summer's tournament.
Coming in at number 12 is Bayern Munich and Germany stopper Manuel Neuer, who has had another excellent campaign at the Allianz Arena.
International record: 64 caps
2015/16: Bayern may have been unable to send Pep Guardiola off with a Champions League win, but they once again strolled to the Bundesliga title, finishing the season 10 points clear of Borussia Dortmund.
Neuer played every single league game for the Bavarian side and amazingly, only had to pick the ball out of his net on 18 occasions.
What can we expect?
With Germany maintaining many of the squad that lifted the World Cup two years ago, it seems unlikely that they will have any issues getting through the group, even if they were occasionally lacklustre in qualifying.
Northern Ireland and Ukraine will most probably set-up against Joachim Low's side simply looking to avoid defeat so Neuer could find himself with very little to do, so it may simply be a case of remaining switched on for the entire game.
However, with Poland claiming a victory over the Germans in qualifying, Neuer's biggest challenge may be keeping their talisman and Bayern teammate Robert Lewandowski at bay.
With a relatively simple group, the knockout stages may be the first time that Neuer has to raise his game to show why he is one of the best stoppers in the world. His ability to adopt a sweeper role saw him re-write the goalkeeping manual, and he will be hoping to prove just as influential in France.
Which Premier League clubs would he suit?
With Guardiola moving to Manchester City ahead of next season, it was hardly surprising that Neuer was linked with following him to the Etihad. However, with the Mirror reporting that he signed a new five-year deal last month, it is unlikely that Premier League fans will be watching the 30-year-old week-in week-out anytime soon, though as long as the Spaniard is in charge of the Citizens, rumours will surely continue.