Both players are set to be given a chance to impress England boss Roy Hodgson at the Etihad.
Alli has not played any first team football in nearly a month, having been suspended for Tottenham's last three games after a clash with West Bromwich Albion's Claudio Yacob last month.
Wilshere is also in desperate need for game time, making just three appearances for Arsenal over the past season having been sidelined for 10 months with a fractured leg.
Both players are now expected to take their place in the centre of a midfield diamond that will also feature Eric Dier and Ross Barkley, which is likely to allow Hodgson room to play Jamie Vardy and Harry Kane up front.
With Sunday's game at the Etihad coming the day after the FA Cup final, Hodgson is unable to pick any Manchester United players, but Liverpool's Jordan Henderson joined up with the rest of the squad on Thursday following his side's 3-1 defeat to Sevilla in the Europa League final and is understood to be keen to impress the England manager.