The Blades have called time on Adkins' spell as manager, with Chris Wilder set to replace him.
Adkins led the Blades to their joint-fourth lowest finish ever this season, leaving them 11th in the standings.
Despite the 51-year-old leading Scunthorpe United and Southampton out of the third tier in recent seasons, the United board have decided enough is enough and will reportedly replace him with Northampton Town boss Chris Wilder.
Shortly after his departure was confirmed, Adkins took to Twitter to express his sadness, before wishing the club well for the future.
"I've met many good people in the 11 months I've lived in Sheffield," Adkins posted. "I wish you well. It saddens me to say goodbye."
I've met many good people in the 11 months I've lived in Sheffield. I wish you well. It saddens me to say goodbye.— Nigel Adkins (@TheNigelAdkins) 12 May 2016
Though by no means universally popular in Sheffield 2, Adkins' tweet received a generally warm response from United fans on Twitter, with many blaming the club's plight on either the players or the board.
That said, there is a consensus it was the Merseysider who talked himself out of the job, having criticised the hostile atmosphere at Bramall Lane in the aftermath of Sunday's home defeat to his former side.
"I've come with, today's opposition for example, Scunthorpe United, as a visiting manager and you know what the atmosphere is going to be like here at Sheffield United. Always has been, probably always will be...that's just the nature of it," Adkins told the Sheffield Star.
Here's how the fans reacted to Adkins' Twitter farewell:
@TheNigelAdkins Thanks for your efforts. Don't think your swipe at the fans on Sunday helped. Final nail in the coffin for many.— Blades Mad (@Blades_Mad) 12 May 2016
@TheNigelAdkins 100% down to the players at your disposal! Shame to see you go but comments re fans were I'll advised. Wish you all the best— Trevor Allison (@Trev_Allison) 12 May 2016
@TheNigelAdkins gave it a go and didn't transpire, good luck with whatever comes your way but remember the fans are everything to a club.— UTB (@EckoBlade) 12 May 2016
@TheNigelAdkins thanks for the effort but why have a dig at us,at me? Do you know how much time & money is spent travelling to games for me?— Newcastle Blades (@Tyneside_Blades) 12 May 2016