The former Celtic star suffered a suspected minor leg fracture in the win over Stoke City and looks set to be ruled out of the FA Cup final and Euro 2016.
Wales boss Chris Coleman is facing the prospect of being without Joe Ledley for his side's Euro 2016 campaign, with the midfielder a major doubt for Crystal Palace's FA Cup final tie with Manchester United later this month.
Fears are growing that Ledley, who has earned 62 caps for his country, has suffered a minor fracture in his leg, after being forced off in the 2-1 win over Stoke City at the weekend.
Coleman is seemingly still determined to give the former Cardiff City star every chance of making it to the finals in France, naming him in the 29-man training squad for this month's trip to a camp in Portugal.
The extent of Ledley's injury has not yet been confirmed, with Palace physio Sean Connelly, who is also part of the FAW set-up, currently monitoring the 29-year-old's situation.
According to Wales Online, Ledley is almost certainly set to miss out on the FA Cup final for the second time in his career, having been ruled out of Cardiff's defeat to Portsmouth in the 2008 showpiece.
Reports suggest a best case scenario will see the midfield anchorman sidelined for three to four weeks, which would take him right up to the start of Wales' first game with Slovakia in Bordeaux on June 11.