The ex-Tigers man believes his former side will edge out Derby County.
The iPro Stadium plays host to the first leg of the tie on Saturday as Steve Bruce's men look to move one step closer to the Premier League following their relegation last season.
But the Tigers come up against a Derby side who beat them twice during the regular campaign, by a 6-0 aggregate which might perhaps give Darren Wassall's side something of a psychological edge in the two-legged clash.
Hughes knows a thing or two about playoff success, having helped Hull into the Premier League via that route in 2008, and the 39-year-old feels that the experience of Bruce and his troops might well prove decisive over the course of the tie.
"I'll always back the experienced guy in games like this because Steve has been in big situations like this and knows how to come through as a winner," Hughes, who had a loan spell with the Rams, said via the Hull Daily Mail.
"He's going to play a big role with all his experience. He's guided teams up from the Championship and he will call upon all that he's learned over the years.
"Darren is showing he's got a talented squad at Derby but over two legs I believe Hull's experience will come out. They're the team I expect to reach Wembley."
The winner of the tie will face either Sheffield Wednesday or Brighton & Hove Albion, who narrowly missed out on automatic promotion, finishing third behind Middlesbrough and champions Burnley.