The England international started the game for the Gunners but had to be withdrawn midway through the opening period after struggling with his knee - an injury he has previously suffered.
After a brief moment of trying to continue, Welbeck’s reaction said it all as he came off to be replaced by Jack Wilshere and headed down the City tunnel shaking his head in disappointment.
Commenting for the BBC after the game, Wenger admits it does not look good for the striker but urges optimism with the European Championships only a month away.
“The first signs look like lateral meniscus. He looks down, and he's not a guy who likes to go off. I'm a bit worried. I don't want to say about the Euros - let's be a bit more optimistic,” Wenger explained.
Welbeck certainly is not the type of character to walk off at the slightest little niggle, suggesting his injury is indeed more serious which would be a huge blow to both the player and England.
The former Manchester United man has missed the majority of the campaign with injury, yet upon his return he has made an immediate impact with the Gunners and earned a regular starting spot.
The 2-2 draw with City keeps Arsene Wenger’s men in the hunt for second spot, and they can secure their place in next season’s Champions League with a home victory over Aston Villa next weekend.