Tottenham Hotspur suffered a setback in their efforts to quell a 21-year itch by losing 2-1 to Southampton at White Hart Lane this afternoon.
Six days after their Premier League title dream went up in smoke, the emphasis for Spurs switched to finishing above North London rivals Arsenal for the first time since 1995.
And Tottenham looked on course to virtually guarantee themselves a second-placed finish behind Leicester City when Heung-Min Son fired them ahead on 16 minutes.
The lead only lasted some 15 minutes, however, as Steven Davis equalised just after the half-hour mark, before curling home a 72nd-minute winner to snatch the victory for Southampton.
But Pochettino will have been bitterly disappointed at full time, and then again at about 6pm when Arsenal won a point in the 2-2 draw at Manchester City to move two points behind the Lilywhites.
Consequently, if the Gunners beat Aston Villa at home on the final day, and Spurs lose at relegation-threatened Newcastle then Arsene Wenger will maintain his immaculate record of never finishing below Spurs.