The Lilywhites, who have finished below Arsene Wenger's side every year since the 1994-95 campaign, sit in pole position to end that hoodoo and snatch the bragging rights for another 12 months at least.
One-upping their neighbours appears to be a forgone conclusion for a while now, but there is an element of doubt after Arsenal beat Norwich City 1-0 on Saturday and former Spurs owner Sugar refuses to rule out another major twist.
You talk about choking Spurs. If Arsenal win their next 2 games and Spurs don't win any more games you will be 2nd https://t.co/uG6uAPHpv0— Lord Sugar (@Lord_Sugar) May 2, 2016
Spurs, whose game in hand is away to Chelsea tonight, must beat the Blues in order to keep alive their slim hopes of winning the Premier League title, with Leicester City eight points ahead after playing 36 games.
But dropped points might be the catalyst behind a last-minute collapse from Pochettino's side, who round off the campaign by hosting in-form Southampton next week, before visiting relegation-threatened Newcastle on the final day.
A Southampton victory on Sunday, coupled with an Arsenal win at Manchester City later on in the day, would see Wenger's side - who face lowly Aston Villa on the final day - leapfrog them into second spot with one game to go.