Klopp insists he will have no hesitations in changing round his Liverpool side if he feels it necessary.
The Reds head into the weekend having played 55 matches this season, with Klopp already demonstrating a willingness to make wholesale changes after making 10 alterations for last weekend's Premier League win at Bournemouth.
That policy may well be set to continue for the visit of Newcastle, who will be looking to lift themselves out of the relegation zone by earning a first league win at Anfield since 1994.
In-form striker Divock Origi limped out of Liverpool's 4-0 derby win over Everton on Wednesday, adding to an injury list that already includes Jordan Henderson, Emre Can, Christian Benteke and Danny Ings.
It means that Daniel Sturridge could be Klopp's only fit striker for Saturday's game, meaning the former Dortmund boss could be tempted to chop and change once again ahead of his side's crucial Europa League semi-final tie with Villarreal.
However, he insists that any players drafted in will have enough quality to see off Rafa Benitez's men, adding that his team are capable of adapting to any new system.
Speaking after their win over Everton, he told the club's official website: “They are only good players. There is not a player in the squad where I think ‘oh, why is he here?’.
“In each game: Stoke – different formation. Bournemouth, Dortmund, Everton – different formations. But we also showed our different styles.
“We are not only a pressing and counter-pressing team, we are a possession team, and it is challenge to bring it together.
“We will work on it and we won’t be finished on it, but we need players.
“They have to do the work, and hopefully we will have enough for the last few games.”
Despite Klopp's confidence, the news is nevertheless likely to make Sunderland and Norwich fans feel a little uneasy about their own relegation battle.
The Wearsiders take on Arsenal at the Stadium of Light on Sunday and are just a point above their local rivals, although they do still have the advantage of having a game in hand on both Newcastle and fellow strugglers Norwich City, who travel to the Gunners the following weekend.