Diouf could be set to return to the scene of his first ever strike for the Potters, who edged their way to a shock 1-0 win in August 2014.
The Senegalese striker was the match-winner during the Potters' last visit to the Etihad, netting to earn his side a shock 1-0 win in August 2014.
While it was a great way of announcing his arrival in England, Diouf has struggled to keep up those goalscoring antics, going 16 games without a strike before grabbing a late equaliser at Chelsea in March.
Four further goalless appearances have followed, leaving the forward with a modest record of four goals from 13 starts and a further 14 substitute appearances so far this term.
Diouf's last appearance arrived when he came off the bench in the 4-1 drubbing at Liverpool, but boss Mark Hughes has not ruled out the possibility of handing him a place in the starting line-up, adding that his previous appearance at the Etihad may give his side a psychological edge.
According to the Stoke Sentinel, Hughes told reporters: "It can have a positive effect.
"But you hear me talk about dealing with the here and now and it's about getting people on to the pitch who can do the job I'm asking of them
"Irrespective of what happened last year, it's about are they training well now.
"I'm not just talking about Mame, but the group as whole, but Mame is very much in my thoughts.
"He's fit and well and raring to go, so we'll see."
If Diouf is handed his first start in over month, he is likely to be given a role out wide, with Hughes looking to plug the gap left by an injury to Xherdan Shaqiri.