The winger endured a difficult spell with the Red Devils.
The 23-year-old joined the Red Devils for £15m (via Mail) after shining with the Eagles when they were in the Championship, but failed to make any kind of impression for the club and was permanently back at Selhurst Park less than two years later having made just two Premier League appearances for United.
And while his failure to make the kind of impact he was expected to make following his big move may see him jeered by sections of the Old Trafford crowd when the two sides meet on Wednesday, Zaha suggested that it will not bother him.
"My time at United has gone and I don't mind if I get booed," he told the Mail.
"I still have Man United followers on Twitter. They might wait until I make a mistake in a game or something, and they'll come out with something like 'that' s why you got sold'.
"I just think you either follow me or you don't. That stage when I was at Man United has gone now and I'm a Crystal Palace player.
"I am just trying to progress in my career, so going back to Old Trafford will be like playing at any other stadium. I am just going to do my best as usual."
While some United fans will be unhappy with the winger's inability to take his opportunity when it came, all of the home supporters will be annoyed if he ends up making a match-winning impact for Alan Pardew's men.
Although his statistics are not the most impressive this season - having scored just two league goals and contributing one assist - he undoubtedly has the ability to cause problems for opposition full-backs so Louis van Gaal will be hoping that he does not end up denting the side's hopes of breaking into the top four.