The Potters somehow earned a 2-2 draw last time around.
The pressure is firmly on Mauricio Pochettino's side as they travel to the Britannia knowing that a victory would take them to within five points of Premier League leaders Leicester City, who slipped up in Sunday's 2-2 draw with West Ham United.
That deficit could, and probably should, be less than what it is, after the Lilywhites dropped two points in the reverse fixture with the Potters this season.
Back in August, Pochettino's boys surrendered a two-goal lead as Stoke netted twice in the final 12 minutes to earn a 2-2 draw at White Hart Lane - the second game in a four-match winless run at the start of the campaign.
But Dier, who helped Tottenham smash Manchester United 3-0 last weekend, admits that the draw against the Potters is a game which he reflects on with "bad feeling" and "great disappointment" - but he hopes to put it right.
“It was a tough time last year away at Stoke and we dropped points against them at the start of the season so obviously we’re looking to put that right,” he said to Spurs' official site.
“When you look at those early games now, they’re the matches I look back on with great disappointment to be honest. From a winning position against Stoke, 2-0 up at home, that’s the sort of game we should be winning and it’s one of the few games this season that I look back on with bad feelings.
“I think with the Manchester United game last week we put one of the scores we had to settle right so hopefully we can do that again this week.”
Mark Hughes's side certainly know what it takes to beat Pochettino's men, having done a league double over them last season which included a 3-0 demolition at the Britannia.
But Tottenham are a different animal this season and they will be confident of avenging those defeats.