This is the final ever FA Cup tie at Upton Park, as West Ham prepare to make their big move to the Olympic Stadium this summer, and will be looking to sign off in style after a superb FA Cup run so far.
Slaven Bilic's men have seen off Wolverhampton Wanderers, Liverpool and Blackburn Rovers so far, and almost edged past Manchester United with Dimitri Payet scoring a stunning free-kick at Old Trafford, before Anthony Martial's equaliser sent the tie to a replay.
United have taken another step back under Louis van Gaal, as Sunday's 3-0 defeat to Tottenham Hotspur was another dismal day for the Red Devils - and few are backing them to have a more successful trip to London this evening.
Pundit Charlie Nicholas has told Sky Sports that he thinks West Ham will coast past United with a 2-0 win, remaining confident that the Hammers will book their place in the semi-finals at Wembley after drawing 3-3 against Arsenal on Saturday.
Many Hammers fans will feel that it's written in the stars for their side to not only win their final ever FA Cup tie at Upton Park, but also cap off an emotional season with FA Cup final success - and Nicholas believes Andy Carroll and Dimitri Payet could be key to those hopes tonight.
"I fancied West Ham before the weekend and I've got no reason to change my mind," said Nicholas. "If United think they played well at Spurs, with one shot on target, they don't know much about winning football matches."
"Andy Carroll was brilliant against Arsenal but I really don't know why people are on the Euros bandwagon after one performance, although he'll be relishing going up against Chris Smalling and Daley Blind. United have never enjoyed going to West Ham, even under Sir Alex Ferguson, so I'm going to back the home side, with Payet relishing the big game again," he added.
What's your prediction for West Ham United v Manchester United?