He told the club's official website how the occasion will not faze him, and plans to enjoy what he feels will be an amazing night.
"It's like when you're playing a final on FIFA and you're playing against your mate,2 he said. "You've all put £20 in the middle and there's £100. The pressure's on, your palms are sweaty, but as you get into the game, the nerves go away and you enjoy it - and that's exactly what it's like."
Sturridge lost his starting spot to teammate Divock Origi for the first leg in Dortmund, but won his place back against Stoke City on Sunday, scoring the second goal for the Reds in their 4-1 victory.
The problem for the former Chelsea and Manchester City striker is that Origi came on in the second half against the Potters and scored two goals, which leaves Liverpool manager Jürgen Klopp with a massive selection dilemma ahead of the game on Thursday night.
Whoever starts for Liverpool, Sturridge insists it will be a fantastic atmosphere at Anfield, and one that every player would love to be involved with.
"It's going to be a great occasion, not just for the players but the fans, for everyone who isn't involved with Liverpool as well - they'll enjoy the match," he said. "It's one of those occasions where you just soak it all up, enjoy it, embrace it, have fun; that's what you live for. It's just going to be a great night for everyone, and you can't let nerves get the better of you."
Sturridge has been nursed back from injury, and has played well upon his return, while Origi has looked dangerous when deputising for the England international, scoring three goals in his last two games.