The Saints head into the game off the back of a defeat, having narrowly lost 1-0 away at league leaders Leicester City last weekend, though their second half display will give Ronald Koeman confidence of getting a positive result this afternoon.
Having picked up two victories prior to the Leicester game, Southampton head into this weekend's game as clear favourites against a struggling Newcastle side.
Newcastle are now six points adrift of safety, and Benitez knows that time is running out for him to save the club and keep them in the Premier League this season.
Now, pundit Mark Lawrenson has told BBC Sport that he thinks Southampton will win the game 2-0, pushing Newcastle ever closer to relegation in the process.
Lawrenson added that the thinks Newcastle and Benitez have a huge problem on their hands - the squad just isn't good enough - and thinks no matter what the former Liverpool manager does with his team, it won't be enough to get a result against Southampton.
"Southampton were a little bit unlucky not to get anything from their 1-0 defeat by leaders Leicester last weekend," said Lawrenson. "Newcastle have got bigger problems, though. They reacted to the appointment of Rafael Benitez but I think everybody knows the issue is that their personnel just are not good enough. Regardless of what Benitez does with his squad this week, I cannot see them getting anything at St Mary's," he added.
What's you prediction for Southampton v Newcastle?