Now seven points behind league leaders Leicester City, Tottenham are running out of time to catch Leicester, and they will watch the Foxes take on Sunderland hours before Mauricio Pochettino's men take on Manchester United at White Hart Lane.
The Red Devils are in the race for a Champions League place, and their 1-0 home win over Everton last weekend was another major boost for manager Louis van Gaal.
United will need to serve up a strong performance in North London to pick up a positive result, and pundit Mark Lawrenson doesn't think they will leave with any points at all.
Lawrenson told BBC Sport that he thinks Tottenham must win this game having lost to Liverpool last week, with a huge gap opening between themselves and Leicester.
Lawrenson confidently claimed that Tottenham will win the game 2-0, and believes United will have one eye on the midweek FA Cup quarter-final replay against West Ham United.
"After dropping a couple of points last week - albeit at Anfield - Tottenham simply have to win this game," said Lawrenson. "I think they will. Manchester United got a great result against Everton but if their manager Louis van Gaal admits the Toffees were the better side and deserved something from the game then you know his side were outplayed. United are back in London on Wednesday night for their FA Cup quarter-final replay against West Ham, which I think will be on their mind at the weekend."
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