The Arsenal midfielder has sat out the whole campaign owing to injury but begins his comeback with a game representing the under-21 side.
Both Wilshere and Rosicky are expected to line up for the Gunners’ junior side against Newcastle on Friday as the midfield duo continue their rehabilitation from injury.
Wilshere has been sidelined throughout the current Premier League campaign after suffering a fibula fracture in July but is set to return to manager Arsene Wenger’s first XI by the end of the season in a bid to seal a place in England’s Euro 2016 squad.
Likewise for Rosicky it has been a season of discontent. The 35-year-old is yet to feature for the north London side after suffering from two long-term injuries. After recovering from a knee injury in January, the Czech midfielder then suffered a thigh muscle strain.
Ahead of the under-21 clash with Newcastle, juniors skipper Pleguezuelo admitted he will be responsible for helping the experienced playmakers.
“It is always good to play with first-team players too, because they are at that first-team level and they will help us a lot,” he told the club's website.
“It is always good to keep learning. It is more of a reason to enjoy the game.
"Playing alongside them is always very good, and if I’m going to be a captain, I need to help them as much as I can and I’m sure they will do the same thing for me.
"Jack is a great player on the ball. The vision he has on the pitch is amazing. Rosicky and him have the experience from a first-team level and it will help our position. They will know what to do with the ball and it will help us a lot offensively."