Paul Merson expects Tottenham to beat Manchester United, but Sunderland to claim a draw with Leicester.
The league leaders visit relegation battling Sunderland on Sunday in the early game, before second placed Tottenham host Manchester United, who are fighting to qualify for a Champions League spot.
Merson has predicted Leicester to suffer defeats in recent weeks against Crystal Palace and Southampton, only to see them win both games 1-0, and this time around he is tipping them to draw.
He explained he expects the game will finish 1-1, arguing that Sunderland need the win more: "They have to win this game, but I don't think it's a must-win for Leicester. They can draw it, but they have to make sure they don't lose."
Merson said that he sees Tottenham beating Manchester United, but feels that if Leicester go to Sunderland and win, then a victory against the Red Devils will probably be futile.
He said: "I don't see anything other than a Tottenham win. Tottenham are a very good team and I expect them to keep the pressure on Leicester. They did very well when they had to play catch up with Bournemouth and beat them quite convincingly. If Leicester don't win then it's a bonus.
"If Leicester do win, I think that will be it. Even if Tottenham also pick up three points, they'd still be seven points behind with five games to go, so for me, this weekend is the big weekend."
Third place Arsenal have a chance to put pressure on both teams by beating West Ham, travelling to Upton Park for the lunchtime kick-off on Saturday.