The 23-year-old winger faces a length spell on the sidelines with multiple knee ligament damage.
According to BBC Sport, Zyro, who joined Wolves from Legia Warsaw in the January transfer window, could be out for a year.
Ikeme has taken to Twitter to send a heartwarming message to Zyro, who has scored three goals and created five chances in five Championship appearances for Wolves.
Gutted for @Michal_Zyro , great pro with a great work ethic. He will comeback stronger I'm sure!!!— Carl Ikeme (@Carl_Ikeme) April 7, 2016
Wolves are 12th in the Championship table at the moment with 52 points from 40 matches. Kenny Jackett’s side are 15 points behind Derby County, who are currently sixth in the standings and occupy the playoff spot.