The North Londoners travel across the capital hoping to keep their slender Premier League title hopes alive by registering what would be a third successive victory.
The Hammers, meanwhile, have a race of their own to run as Slaven Bilic's side chase fourth-placed Manchester City - who sit four points ahead - for a Champions League qualification spot.
Indeed, Cottee feels that the Gunners are inconsistent but warns that writing them off would be "very dangerous", though the Irons legend still reckons the hosts will come out on top with a narrow victory.
"Arsenal are the visitors and it will be a massive game," he wrote in London 24. "They have been a bit inconsistent tand that has probably cost them their chance of winning the title, but they are still very dangerous.
"I am more confident about the game, though, and I will go for a big 2-1 victory for us. COYI!!"
Bilic and co go into the clash on the back of a three-match winless run in all competitions, with last Saturday's 2-2 draw at home to Crystal Palace being the latest setback in their top-four bid.
They have, however, specialised in upsetting England's elite this season, with Chelsea, Liverpool, Tottenham Hotspur and Manchester City all falling foul of the Irons - along with Arsenal themselves, on the opening weekend of the 2015-16 campaign.