Dier has accumulated nine league bookings this season, but will avoid a ban if his tenth yellow card arrives after Sunday's amnesty.
Should the England man pick up a caution against Manchester United, he would sit Spurs' next two matches against Stoke City and West Bromwich Albion.
And, having slipped to seven points behind leaders Leicester City at the weekend, the north Londoners cannot afford to lose one of their key men at such an important part of the campaign.
Dier was uncharacteristically shy during Saturday's 1-1 draw against Liverpool, with the prospect of a ban potentially playing on his mind.
The 21-year-old failed to make a single tackle at Anfield, which is almost two fewer than average in this season's Premier League.
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Tottenham are short of like-for-like replacements for Dier, with Nabil Bentaleb ruled out for the rest of the campaign.
It is likely that one of Ryan Mason or Tom Carroll would fill in for the former Sporting player in the event that his suspension is forthcoming.