The 24-year-old missed Spurs' last game due to an injury picked up on international duty.
The attacking midfielder played no part in Spurs' 1-1 draw with Liverpool on Saturday after sustaining a calf injury on international duty with Argentina, but the London Evening Standard claims that the title chasers are hopeful that he will be available for when Louis van Gaal's men visit White Hart Lane.
With the draw against the Reds, and Leicester's win over Southampton the next day, leaving Mauricio Pochettino's side seven points adrift of the Foxes, having the 24-year-old in contention to play will be a major boost for the club as they try to stay in touch with the league leaders.
Like many of the Tottenham squad, Lamela has clearly made large strides forward from the player he was during his first season in England, having contributed three goals and five assists in the top flight this term.
And if he is able to shake off his injury in time for this weekend's clash, then Pochettino will be hoping that the former Roma star is able to produce the moments of magic that ensure that Spurs remain in the title race for as long as possible.