The Hammers saw Everton awarded a penalty when the foul was clearly outside the box in their game at Goodison Park last month.
That could have made it 3-0 to the Toffees but Romelu Lukaku missed and Slaven Bilic's side somehow managed to claw their way back to win 3-2 in the last 12 minutes.
Hammers denied by officials four games in a row
But the East Londoners were then denied a famous win over Manchester United at Old Trafford for a place in the semi-finals of the FA Cup with three major decisions all going against them.
Dimitri Payet should have had a clear penalty, was inexplicably adjudged to have fouled Varela when through on goal and Anthony Martial scored a late equaliser despite a clear foul on Hammers 'keeper Darren Randolph.
Slaven Bilic's side were forced to settle for a 1-1 draw that day and a replay.
At Stamford Bridge, where the Hammers haven't won since 2003, they were deservedly and comfortably leading fierce rivals Chelsea 2-1 and looked set to leapfrog Manchester City into the Champions League places.
That was until another howler from the match officials saw the Blues awarded a penalty that never was in the dying seconds of the game, again it was a foul outside the box.
It wasn't the only controversy either.
In first half stoppage time the referee pushed the Hammers wall back 12 yards, with the protestation of West Ham's players going ignored. Fabregas stepped up and converted the free-kick, made all the easier for him with West Ham's wall completely powerless to stop it.
But just when the club thought it couldn't get any worse, it did when Cheikhou Kouyate was harshly sent off by Mark Clattenburg with the Hammers winning 2-1 against the Eagles last time out.
Palace went on to equalise making it four dropped points in two games as a direct result of refereeing blunders.
Those four points would see West Ham sitting one point above Manchester City in fourth place.
And such is the feeling of injustice exasperated Hammers chief David Gold and the son of his fellow co-owner David Sullivan have called for change.
'Tehnology the only way'
Speaking on Twitter, Gold said: "Disappointing decision by Mark Clattenburg to red card Kouyate which we will be appealing.
"We must give referee's more TV replay help.
"If the ref was mic'd up to a retired experience ref who had instant TV replays, poor decisions would be reduced."
Disappointing decision by Mark Clattenburg to red card Kouyate which we will be appealing. We must give referee's more TV replay help. dg— David Gold (@davidgold) April 2, 2016
If the ref was miked up to a retired experience ref. who had instant TV replays, poor decisions would be reduced. dg https://t.co/SSwltzjzk9— David Gold (@davidgold) April 2, 2016
And Dave Sullivan, the son of David, also took to Twitter to air his views.
"Another huge decision which has gone wrongly against us," Sullivan junior said on Twitter.
"Refereeing/ officiating at the top level needs a rethink. Technology needed.
"There is no corruption it's just too many mistakes being made and more help is needed. Technology is the way."
Another huge decision which has gone wrongly against us. Refereeing/ officiating at the top level needs a rethink. Technology needed.— DAVE SULLIVAN JNR (@DaveSulley) April 2, 2016