The two West Ham stars are 'close' to returning from injury.
West Ham United head of medical and sports science Stijn Vandenbroucke says the club only have two injuries at present but that both Sam Byram and James Collins are close to making a return to action, according to the club's official website.
Indeed, the duo will train with the first team next week and West Ham will soon be able to call on their services.
Both defenders have impressed this season, with Collins defying expectations at centre-back and Byram settling in at right-back after Carl Jenkinson's long-term injury.
"We have two injuries at the moment with Sam Byram and James Collins but both players are close to making a return and will train with the first team next week."
The Hammers will need all their resources available to them ahead of a run-in that provides them with a very realistic chance indeed to clinch a Champions League place.
Even without Collins and Byram, though, West Ham are well set in all other areas.
Ahead of their Premier League clash against Crystal Palace, the east London side's biggest threat is complacency.
In terms of ability and form, West Ham are heavy favourites. So the only risk is over-confidence.