The Hammers are unbeaten in their last eight games in all competitions.
The encounter pits two sides against each other that went into the international break off the back of hugely contrasting runs of form. While Slaven Bilic's men have not lost in their last eight games in all competitions, winning four during that spell - including a fantastic victory over title-challengers Tottenham - the Eagles have not won in the top flight since December, a run which now stretches back 13 games.
Unsurprisingly therefore, Keown suggested that it will be the Hammers that secure the three points, and he explained why he is backing the home side to get the better of Alan Pardew's men.
"This is the best West Ham team we’ve seen in years and if they win they could be in the top four by Saturday night. Alan Pardew won’t want to lose on his old hunting ground and Palace are a threat on the break, but they have conceded far too many goals. They are almost back to where they were when Pardew took over. They have the players to get out of trouble but this does not look like a game they will win," he told the Daily Mail.
While Keown is confident that the Irons will extend their unbeaten run, and the Premier League form book seems to back that argument, Palace will take belief from the way that they have performed in the FA Cup this term.
Amongst their poor league form, they have won all of their games in the cup, knocking out three top flight teams in the process. And they will surely have to be at the level they were at when they beat the likes of Southampton, Stoke and Spurs if they hope to prove Keown wrong, given the way that West Ham have played in recent weeks.