The national team are running low on attacking options.
The team have been hit by a series of withdrawals with Kevin Doyle, Robbie Keane, Jonathan Walters and Daryl Murphy all out of the upcoming game (via Mail), meaning that Southampton's Shane Long goes into the fixture as their only recognised forward.
But O'Neill suggested that he could turn to McClean to lead the line if required.
"We can adjust things. James McClean has played up front before. I have seen him play for Wigan there, where he has done exceptionally well," he told the Mail.
While the 26-year-old's primary focus is not to score goals, but to create them for his teammates, his goalscoring record is still fairly underwhelming given the obvious talent he possesses.
For the Baggies, he has scored just two Premier League goals, while he failed to make it into double figures at either of his previous clubs, Wigan or Sunderland.
However, his ability to run at defenders and use his trickery to get the better of those marking him may help him if O'Neill does want him to move into a more central position to become the team's main goalscoring threat.