Both players only joined the Premier League club in the summer.
The two players arrived before the start of this season with United paying around £50m in total (via The Sun and BBC Sport), but it appears that the club's hierarchy have already lost faith in the idea that they are the kind of players that will take the Red Devils back into the title picture in the Premier League.
Depay moved to Old Trafford after enjoying a sensational season with PSV Eindhoven, where he inspired them to the Eredivisie title with bags of goals.
But while he has created moments of excitement when he has had the ball at his feet, he has not shown anywhere near enough end product to justify his fee. He has scored just two goals in the league, and is yet to register an assist.
Meanwhile, Schneiderlin could perhaps be considered unlucky if he was to be made something of a scapegoat following the club's disappointing season. The former Southampton stalwart has done little wrong, but perhaps his lack of attacking intent has contributed to the fans' frustration over the team's style of play.
Should the pair depart in the summer, it will surely have to persuade United to take a look at their structure as it is a similar story to what happened to Angel Di Maria last season.
The Argentine arrived for a huge fee, but left soon after having fallen out of favour and being discarded as a big-money flop. However, with his move to Paris Saint-Germain proving that he is still one of the most talented wingers in the game, the finger of blame regarding why the move did not work out should really move back to United.
And if the pair move on and thrive elsewhere, then the calls for a complete overhaul at the club will surely become much louder.