And the main advantage Kane has over the Liverpool striker is fitness and game time, the pundit has suggested.
Merson told Sky: "Harry Kane has to play. He plays up front on his own for Tottenham and he's looking like winning the Golden Boot at the moment.
"Daniel Sturridge is a top player but I don't think he has had enough game time. Can he play six or seven games in a short space of time? I don't think he can. So Kane has to start."
It's a fair argument. The Spurs striker is the man in front of goal at the moment.
But the advantage Sturridge has is his ability to play wide, albeit less effectively. The Liverpool striker could work alongside Kane and, if Roy Hodgson knows what he's doing, could change a game brilliantly as a super sub.
Ultimately, the Reds forward may not be able to last several matches - but his lack of game time this season means he will be fresher than most others.
That could give England a huge edge from the bench, even if Tottenham's Kane should be the one starting.