Which of these three sides stand the best chance of overtaking Manchester City in fourth place?
While the race for the title now appears to be between Leicester City and Tottenham Hotspur, the top four is far from settled.
Arsenal appear to have made third place theirs, but Manchester City’s poor run of form since the announcement of Pep Guardiola means they are in danger of dropping out.
But which of those three teams face the best set of fixtures to help them ensure they can make it in?
It had looked to be a disastrous season for Southampton, with a poor run of form before the turn of the year seeing them at the wrong end of the table.
Instead, a change of formation and the return of goalkeeper Fraser Forster have seen them quickly rise up the table and now be in contention for a top four place.
They face a tough run in though as they take on Spurs, Manchester City and leaders Leicester in their last eight games. Games against relegation threatened Newcastle, Aston Villa and Crystal Palace softens the blow however.
Saints remaining games: Leicester City (A), Newcastle United (H), Everton (A), Aston Villa (A), Manchester City (H), Tottenham Hotspur (A) and Crystal Palace (H).
It has been another disappointing campaign for Manchester United, who have failed to impress under Louis van Gaal again.
Indeed, it seems the Dutchman could be on his way out of Old Trafford, with widespread reports that Jose Mourinho is waiting in the wings.
Securing a top four place could save the Dutchman, although their run of games won’t be easy as they take on Leicester, West Ham and Tottenham with two of those games away from home.
United remaining games: Everton (H), Tottenham (A), Aston Villa (H), Crystal Palace (H), Leicester City (H), Norwich City (A), West Ham (A) and Bournemouth (H).
West Ham United
Of the three contenders vying for Manchester City’s place, it is easily the Hammers that look the most likely to do it.
They have been hugely impressive under Slaven Bilic and with Dimitri Payet continuing to shine look set to leave Upton Park on a high.
Their remaining games are favourable though, with Crystal Palace, Watford, Swansea all in the bottom half. Home games against Arsenal and Manchester United are sure to be crucial though.
West Ham remaining games: Crystal Palace (H), Arsenal (H), Leicester City (A), Watford (H), West Brom (A), Swansea (H), Manchester United (H) and Stoke (A).