The Manchester United veteran has been out of sorts all season for club and country.
The World Cup winner picked up the injury in training on Tuesday and has been sent to Munich to undertake an MRI scan.
The former Bayern Munich man has 114 caps for Germany along with eight Bundesliga titles and a Champions League medal.
While Schweinsteiger has not performed to his own high standards this season, his likely absence will be a massive blow to Germany heading into the Euros and to Manchester United as they look to navigate their way to Champions League qualification.
His experience will be sorely missed, especially as United's increasingly young side tackle the last two months of the season.
He will be 32 by the time United kick off their 2016/17 campaign, and it will be interesting to see how this current injury will affect him going forward. After all, he had only just returned from a two-month spell on the sidelines due to a separate knee injury.
Both United and Germany will be hoping the trophy-laden midfield general's injury is not as bad as first feared. Depending on the severity of the damage, he could be missing for up to 10 weeks.
It was also reported that Arsenal's Mesut Ozil and Bayer Leverkusen's Karim Bellarabi sat out today's training session.