Noble has spent his entire career with the Hammers, having progressed through their youth season and into the first-team set-up.
Since making his debut in 2005, the 28-year-old midfielder has played 340 times for the East London side, and his dedication was rewarded at the beginning of the season when head coach Slaven Bilic named him captain.
The likes of Ferdinand and other legends such as Paolo Di Canio, Ian Bishop and and Trevor Sinclair will also take part in front of a sold out 35,000 capacity in this last ever season at the Boleyn Ground.
And Ferdinand, who will take to the field alongside brother Anton who also played for the Hammers, has taken to social media to show he is taking the occasion seriously.
Posting on his official Instagram account, the former Manchester United hero could not hide his excitement at his homecoming while doing a gym workout in preparation.
"Morning gym sesh ready for Mark Noble testimonial," Ferdinand said.
"Looking forward to putting my boots on for the last time at Upton Park. Come on your Irons!"
Ferdinand retired from football last year but clearly keeps himself in shape and has played against Noble on numerous occasions.
Rio is a boyhood Hammer and also spent time around Noble and his West Ham teammates while brother Anton was with the club.
He recently described Upton Park as a 'beautiful place to play football' and said he would miss it when the club leaves undoubtedly jumped at the chance to be involved in the game.