The Sunderland striker has scored 14 goals this season.
The local rivals are both in serious danger of relegation from the Premier League to the Championship and both need a result tomorrow.
One former Newcastle United midfielder does however worry about The Magpies chances - because of one specific reason.
The 50-year-old told Soccer AM this morning:
"Sunderland have got a goalscorer in Jermain Defoe. Which worries me slightly.
"You can be as tight as you like at the back and keep goals out but you need someone to score goals.
"At this moment in time Newcastle can't score. That worries me a little bit. You look at the teams that usually get out of trouble and they usually have someone who can score goals."
Newcastle have plenty of striking options but they have not been thriving in the Premier League this season.
Defoe in the meanwhile is a more experienced option and has scored goals in the Premier League for the likes of Tottenham, West Ham and Portsmouth. He has netted 14 goals this season for Sunderland and his goals may very much keep Newcastle in the league this term.
Meanwhile the likes of Aleksandar Mitrovic, Papiss Cisse, Ayoze Perez, Seydou Doumbia and Emmanuel Riviere combined have managed just 13 goals between them.
This fact, in itself, backs up Lee's concerns.