The youngster was called into Gareth Southgate's England Under-21 squad on Thursday.
The 20-year-old recently returned from a long-term hamstring problem, but put the two things on par with one another when asked about his toughest moment.
"Everything was going well, even the start of this season I felt I was performing well.
"It (the injury) was very mentally demanding. It’s been one of the worst moments of my career."
Hause, who was born in the shadows of Upton Park in Redbridge, spent eight years with the Hammers before being let go as a 16-year-old in 2011.
A three-month loan to Gillingham followed, before Hause began to establish himself in Kenny Jackett's side which finished outside the play-offs on goal difference only last term.
His form led to an England Under-21 call in September, but the injury he suffered in October has hampered both his and Wolves' progress this time around.
The Black Country side are currently 12th in the standings, but still have ambitions of making the play-offs despite being 12 points behind sixth-place Sheffield Wednesday.
Hause, who can also play at left-back, has appeared on 36 occasions for Wolves, but is yet to open his goalscoring account.