Sunderland are set to face Newcastle United at St. James' Park on Sunday.
The Magpies and the Black Cats are set to meet at St. James’ Park in a crucial Tyne-Wear derby on Sunday.
History is in Sunderland’s favour, as they have won the last six meetings between the two sides, but Redknapp has a feeling that this trend is about to come to an end.
"I’ve got a feeling that things might change this weekend, and not because of Rafael Benitez," Redknapp said. "When records are like this, something has to give.
"I think whoever wins this one will stay up, as it’ll be such a kick in the teeth for whoever loses.
"I’m sure Sunderland fans will be saying ‘how can you’ but I just think that Benitez going in there might make a bit of a difference, and I think it’ll be 2-1 with Wijnaldum scoring."
Benitez’s appointment at Newcastle has increased optimism about their survival chances.
As things stand, the Tynesiders are in 19th place in the Premier League table - and they are one point adrift of safety.
Benitez’s first match in charge came on Monday, but the Spaniard could not inspire his new side to victory, as they fell to a 1-0 defeat against Leicester City.
Newcastle’s performance in the contest was much improved, but they will need to play even better to beat Sunderland at the weekend.
The Black Cats have produced some excellent displays in recent weeks, and if they are able to win at St. James’ Park they will move four points clear of their local rivals.